“The role of diagnostics in the restoration project”

Over the last few years, in the field of restoration and conservation, the techniques used to evaluate the extent of damage are becoming increasingly more important before carrying out any work on a historical building. The diagnostic phase is the instrumental, methodological and procedural means of guidance and control during the preliminary cognitive examinations of the building which requires work. For this reason, in the restoration project, the procedural sequence is heavily based to the cognitive phase. In order to evaluate the conservational state of a structure correctly, it is necessary to understand the symptoms of the degradation and the principal cause. When this correlation is unclear there follows the planning and carrying out of a series of cognitive investigations. There is a preference in using indirectly destructive or non destructive investigative techniques to evaluate the state of the damage and degradation of monuments. These tests, which are carried out in situ, are based on identifying global physical properties present in the walls or the walls’ components and provide information about their behaviour. This study presents the planning and implementation of a series of surveys, carried out in situ, preliminary to structural consolidation and redevelopment work on a medieval castle: the castle of Cancellara (South Italy)

Persepsi Pemustaka Pada Layanan Perpustakaan Keliling Di Alun-alun Mini Ungaran Kabupaten Semarang

Judul skripsi ini adalah “Persepsi Pemustaka pada Layanan Perpustakaan Keliling di Alun-alun Mini Ungaran Kabupaten Semarang”. Tujuan penelitian ini adalah untuk mengetahui bagaimana persepsi pemustaka pada layanan perpustakaan keliling di Alun-alun Mini Ungaran Kabupaten Semarang. Skripsi ini menggunakan metode penelitian kualitatif jenis deskriptif bentuk studi kasus. Dalam skripsi ini diambil lima informan yang memenuhi kriteria sebagai informan. Teknik pengambilan sampel dilakukan dengan teknik Purposive sampling. Teknik pengumpulan data menggunakan observasi, dokumen, dan wawancara. Pengolahan data menggunakan reduksi data dengan membuat transkrip, mengelompokkan, kemudian membuat analisis. Penyajian data dilakukan dengan mendeskripsikan hasil dari reduksi data serta menarik kesimpulan. Penelitian ini melihat dari segi bukti langsung, kehandalan, daya tanggap, jaminan, dan empati. Hasil analisis diketahui bahwa persepsi pemustaka pada layanan perpustakaan keliling terkait dengan bukti langsung pemustaka mengetahui adanya layanan perpustakaan keliling, letak perpustakaan keliling sudah strategis, fasilitas sudah bagus, koleksi lumayan lengkap, perilaku dan penampilan petugas baik, rapi, trampil, dan sehat. Kehandalan sudah datang tepat waktu, waktu yang disediakan cukup memadai, dan petugas sudah tepat dan tidak berbelit-belit. Daya tanggap petugas sudah cepat melayani dan merespon, petugas sudah sigap, dan menawarkan bantuan. Jaminan tempat perpustakaan keliling aman dan nyaman, petugas tidak memberikan alternatif koleksi lain, petugas sudah sopan tetapi kurang ramah. Empati petugas peduli kritikan, sabar, telaten, dan objektif. Sebagian besar layanan perpustakaan keliling di Alun-alun Mini Ungaran Kabupaten Semarang sudah bagus. Walaupun masih ada kekurangan yang disampaikan pemustaka, meliputi jumlah koleksi yang kurang beragam, petugas kurang ramah, serta pelayanan petugas yang dirasa masih kurang memuaskan

THE CHORÁ OF PATMOS (GREECE): ANALYSIS OF ARCHITECTURAL HERITAGE, IDENTIFICATION OF RISKS AND ASSESSMENT OF IMPACTS

Abstract. The Historic Center (Chorá) of Patmos, located in one of the Dodecanese Islands of Greece, was inscribed in the World Heritage List in 1999. The morphological feature, the housing typologies and the building techniques that characterize the Chorá provide an authentic and astonishing expression of the stylistic and typological models of the vernacular architecture of the Greek islands. This paper presents part of the research carried out on the Chorá of Patmos, within the 3D Past project, funded by the European Creative Europe program. The first part illustrates the results of the research concerning the analysis of the material components of the architectural heritage of Patmos: the urban structure, the evolution of the main architectural typologies, the feature of the main building systems. The second part of the paper presents the application of the Heritage Impact Assessment (HIA), a tool for the management of site transformations and in particular for identifying, forecasting and evaluating the impact of potential development on the Outstanding Universal Value (OUV) of the properties. In the case of Patmos the application of HIA can provide an important contribution to manage changes and future transformations in order to preserve the cultural significance of the site and ensure its sustainable development

Direct Differential Photometric Stereo Shape Recovery of Diffuse and Specular Surfaces

This is the author accepted manuscript. The final version is available from Springer via http://dx.doi.org/10.1007/s10851-016-0633-0Recovering the 3D shape of an object from shading is a challenging problem due to the complexity of modeling light propagation and surface reflections. Photometric Stereo (PS) is broadly considered a suitable approach for high-resolution shape recovery, but its functionality is restricted to a limited set of object surfaces and controlled lighting setup. In particular, PS models generally consider reflection from objects as purely diffuse, with specularities being regarded as a nuisance that breaks down shape reconstruction. This is a serious drawback for implementing PS approaches, since most common materials have prominent specular components. In this paper, we propose a PS model that solves the problem for both diffuse and specular components aimed at shape recovery of generic objects with the approach being independent of the albedo values thanks to the image ratio formulation used. Notably, we show that by including specularities, it is possible to solve the PS problem for a minimal number of three images using a setup with three calibrated lights and a standard industrial camera. Even if an initial separation of diffuse and specular components is still required for each input image, experimental results on synthetic and real objects demonstrate the feasibility of our approach for shape reconstruction of complex geometries.The first author acknowledges the support of INDAM under the GNCS research Project “Metodi numerici per la regolarizzazione nella ricostruzione feature-preserving di dati.

Spacecraft performance analysis

Spacecraft performance and life analysi

Anti-cancer Prodrugs-Three Decades of Design

The conventional old treatment method for cancer therapy is associated with severe side effects along with several limitations. Therefore, searching and developing new methods for cancer became crucial. This mini review was devoted on the design and synthesis of prodrugs for cancer treatment. The methods discussed include targeted prodrugs which are depending on the presence of unique cellular conditions at the desired target, especially the availability of certain enzymes and transporters at these target sites, antibody directed enzyme prodrug therapy (ADEPT), gene-directed enzyme prodrug therapy (GDEPT) which is considered one of the important strategies for the treatment of cancer and prodrugs based on enzyme models that have been advocated to understand enzyme catalysis. In this approach, a design of prodrugs is accomplished using computational calculations based on molecular orbital and molecular mechanics methods. Correlations between experimental and calculated rate values for some intramolecular processes provided a tool to predict thermodynamic and kinetic parameters for intramolecular processes that can be utilized as prodrugs linkers. This approach does not require any enzyme to catalyze the prodrug interconversion. The interconversion rate is solely dependent on the factors govern the limiting step of the intramolecular process

Antibacterial Predrugs-from 1899 till 2015

The predrug (prodrug) term involves chemically modified inert compound which upon an administration releases the active parent drug to elicit its pharmacological response within the body. For many years, the predrug strategy has been extensively developed to solve many unwanted drug properties. This approach has several advantages over conventional drug administration and it has the potential to be quite effective method for the treatment of diseases in the future. In this mini-review we describe a number of antibacterial agents‘ predrugs, and the ways by which predrug strategy was exploited to overcome many pharmaceutical and pharmacokinetic problems that the parent active antibacterial drugs suffer from such as, low bioavailability by increasing or decreasing lipophilicity, site selectivity for higher absorption and less toxicity, short duration of action to increase patient compliance, rapid metabolism to increase oral bioavailability and masking bitter sensation which is crucial for geriatric and pediatric patient compliance

A sensitivity study of triboson production processes to dimension-6 EFT operators at the LHC

We present the first parton-level study of anomalous effects in triboson production in both fully and semi-leptonic channels in proton-proton collisions at 13TeV at the Large Hadron Collider (LHC). The sensitivity to anomalies induced by a minimal set of bosonic dimension-6 operators from the Warsaw basis is evaluated with specific analyses for each final state. A likelihood-based strategy is employed to assess the most sensitive kinematic observables per channel, where the contribution of Effective Field Theory operators is parameterized at either the linear or quadratic level. The impact of the mutual interference terms of pairs of operators on the sensitivity is also examined. This benchmark study explores the complementarity and overlap in sensitivity between different triboson measurements and paves the way for future analyses at the LHC experiments. The statistical combination of the considered final states allows setting stringent bounds on five bosonic Wilson coefficients